The Mongoose to his Spider.

“Absolutely we wanted to have a villain not only who would fulfill the character needs but somebody who could entertain the audience on a visceral level and provide great visuals, something we haven’t seen before, and create a real challenge and great foe for Spider-Man and his unique spidery, spider-like powers.” Sam Raimi announces he’s picked a villain for Spiderman 3, but won’t say who it is. After the Green Goblin/Hobgoblin and Dr. Octopus, Spiderman doesn’t have all that many more culturally resonant arch-nemeses in his Rogue’s Gallery: It’d be hard to see them building a movie around Mysterio, Electro, The Vulture, The Sandman, or Kraven the Hunter. And, while Green Goblin II, The Lizard, and Man-Wolf were all alluded to in Spidey II, only the Harry Osborne/James Franco storyline seems weighty enough to build a third feature around, and I’m not sure they’d want to repeat the Goblin so quickly. So, unless Webhead takes on the entire Sinister Six, I think it’s a pretty good bet we’ll be seeing Venom in the next installment. He got really quickly overused in the McFarlane era, which is right around where I stopped reading Spidey (give or take a few issues of the Straczynski run.) But he should also be an FX dream on film if done right.