Life Everlasting.

“The scientists joined old and young mice for five weeks and then examined them. The muscles of the old mice had healed about as quickly as those of the young mice…The young mice, on the other hand, had effectively grown prematurely old.”

Take that, Van Helsing: Per PBS’s NOVA, research increasingly suggests that transfusions of young blood hold the secret to slowing or reversing aging. “We can turn back the clock instead of slowing the clock down,” said Dr. Toren Finkel, director of the Center for Molecular Medicine at the National Heart, Lung and Blood Institute.”

(Unless, of course, it’s all about the jellyfish.)

Microscopic Monets.

“Each ovary of the female fruit fly houses multiple ovarioles or ‘assembly lines’ in which individual egg chambers develop into fully formed fly eggs…In this picture, cross-sections of ten ovarioles from different female fruit flies are arranged with stem cells and early stage egg chambers at the center, and the more mature chambers at the periphery. The nucleus of each cell is stained yellow/orange. The cell membranes are stained blue.”

As written up by Aatish Bhatia at Wired, the winners of Princeton’s annual Art of Science competition are announced. “Among the entries are some wonderful ‘oops’ moments, where an experiment goes beautifully wrong, revealing art where you might not have expected to see it…But most of these submissions aren’t accidents. Many of these pieces reveal form, structure, and beauty hidden at a scale that our eyes can’t perceive.”

A, C, G, T…X, Y?

“While all possible combinations of G, T, C, and A are already in use — AAG for example, creates an amino acid called lysine, and TAA signifies the end of a code of DNA — new letters exponentially increase the number of possible codons and give researchers the ability to recode the genetic framework without needing to rewrite or erase what life has already created. Codons like XYA or TGX, for example, could be programmed to build new types of amino acids, which could configure new proteins.”

In an impressive breakthrough, biologists successfully expand the genetic alphabet of a living organism from four to six, opening up all kinds of possibilities for everything from pharmaceuticals to new life. “‘This is a very major accomplishment in our efforts to inch towards a synthetic biology,’ says Steven Benner, a synthetic biologist at the Foundation for Applied Molecular Evolution who was not involved in the study. ‘Many in the broader community thought that Floyd’s result would be impossible to achieve.'”

Of Mice and Men.

“‘People have not paid attention to this in the entire history of scientific research of animals,’ says Jeffrey Mogil, a pain researcher at McGill University and lead author of the study. ‘I think that it may have confounded, to whatever degree, some very large subset of existing research.'”

Sorry, Lenny: A new study finds a potentially problematic issue for decades of research: Mice are scared of men (or males of any species). ‘If you’re doing a liver cell study, the cells came from a rat that was sacrificed either by a man or a woman,’ Mogil says. As a result, ‘its stress levels would be in very different states.’ This, he says, could have an effect on the functioning of the liver cell in that later experiment.”

Better Living Through Nanotech.

“A team of chemists and engineers accomplished the feat by inserting tiny synthetic motors inside living cells, moving them around with ultrasonic waves and steering them magnetically. Clearly, it’s not as elegant as the self-propelled, self-guided nanobots envisaged by futurists and scifi, but it’s an important first step. These same basic principles could conceivably be refined and upgraded.”

A glimpse of the future: A Penn State team manage to insert synthetic nanomotors into living cells for the first time. “We might be able to use nanomotors to treat cancer and other diseases by mechanically manipulating cells from the inside. Nanomotors could perform intracellular surgery and deliver drugs noninvasively to living tissues.”

The End of All Things (Pt. 6).

“The worst mass extinction of all time came about 250 million years ago [the Permian-Triassic extinction event]. There’s a pretty good consensus there that this was caused by a huge volcanic event that went on for a long time and released a lot of carbon-dioxide into the atmosphere. That is pretty ominous considering that we are releasing a lot of CO2 into the atmosphere and people increasingly are drawing parallels between the two events.”

The WP’s Brad Plumer talks with Elizabeth Kolber about her new book, The Sixth Extinction, and the many grim portents for life on our planet these days. “I think many scientists would say that what we’re doing to the chemistry of the oceans is the most significant. One-third of the carbon-dioxide that we pump into the air ends up in the oceans almost right away, and when CO2 dissolves in water, it forms an acid, that’s just an unfortunate fact.”

Of Mice and Memory.

“‘Prof Roger Morris, from King’s College London, said: “This finding, I suspect, will be judged by history as a turning point in the search for medicines to control and prevent Alzheimer’s disease.’ He told the BBC a cure for Alzheimer’s was not imminent but: I’m very excited, it’s the first proof in any living animal that you can delay neurodegeneration. The world won’t change tomorrow, but this is a landmark study.'”

Some good news for a change, by way of Dangerous Meta: Scientists have developed (for mice, at least) what appears to be a breakthrough drug that could prevent Alzheimers and other neurodegenerative diseases like Parkinson’s(!):

“When a virus hijacks a brain cell it leads to a build-up of viral proteins. Cells respond by shutting down nearly all protein production in order to halt the virus’s spread. However, many neurodegenerative diseases involve the production of faulty or ‘misfolded’ proteins. These activate the same defences, but with more severe consequences…The researchers used a compound which prevented those defence mechanisms kicking in and in turn halted neurodegeneration.”

All We Have is Now.

“Humans are good at a lot of things, but putting time in perspective is not one of them…If the Earth formed at midnight and the present moment is the next midnight, 24 hours later, modern humans have been around since 11:59:59pm—1 second. And if human history itself spans 24 hours from one midnight to the next, 14 minutes represents the time since Christ.”

Time? What time do you think we have? As has been going around the Interweb, a series of intriguing timelines ranging from last year to the age of the universe. Among the interesting facts pointed out: “The T-Rex is closer in time to seeing a Justin Bieber concert than seeing a live stegosaurus.” Also: “When we refer to the most ancient of ancient history, we are still just talking about…less than 3% of the time that humans who look like us have existed.”

Chasing Darkness.

“How dark it would have been—imagine leaning out your door and, on the darkest nights, not being able to see more than a few feet in any direction. Historian Peter Baldwin describes as ‘downright perilous’ the streets in early American cities, with few paved and then those only with cobblestones…What lights did exist were intended only as beacons or guides rather than to illuminate the night. The New York street lanterns burning whale oil were, in 1761, merely ‘yellow specks engulfed by darkness,’ and, even more than 100 years later, its gas lamps were still ‘faint as a row of invalid glow-worms.'”

In Slate, Paul Bogart describes (and laments) the end of night all across the world. “With at least 30 percent of all vertebrates and more than 60 percent of all invertebrates worldwide nocturnal, and with many of the rest crepuscular, [the] implications are enormous.”

We…learn. We…feed.

“‘Slime mould’s remarkable problem-solving capabilities are well-documented and include finding the shortest path between different food sources. It also displays memory, in a similar way to a novel electrical component called a memristor, which has in turn been likened to the functionality of biological brains. ‘It’s one of the simplest organisms that can learn,’ says Gale.”

And now, IT HAS A FACE. Scientists program an old-timey robot to dramatize the electrical signals emanating from slime mold. In a 100,000 years, this is going to seem like one of those Skynet-level bad ideas. And the hat is particularly creepy touch — Very Something Wicked This Way Comes.